GHK Cu vs NAD+: Which Longevity Peptide Should You Take or Stack? Frontiers Exploring the beneficial effects of GHK Cu on an experimental model of colitis and the underlying mechanisms How GHK Peptide Works Signaling GHK acts as a switch for skin repair: Interacts with adenosine receptors reduces inflammation Activates MAPK ERK, PI3K Akt, TGF pathways Stimulates fibroblasts & keratinocytes boosts collagen, elastin SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons Cell Death & Disease